医疗特长：从事消化内科临床工作30余年；具有丰富的临床经验，致力胃食管反流病，消化性溃疡等酸相关性疾病以及肝胆疾病的诊治。擅长各类消化系统常见疾病，包括胃食管反流病、慢性胃炎、贲门失弛缓症、功能性食管疾病、消化性溃疡、急性肠炎、肠易激综合征、肝炎、脂肪肝、胆囊炎、胆管炎等。熟悉掌握消化内镜检查及治疗。

主要教育和工作经历：

教授，主任医师，博士生导师。中山大学内科学博士研究生，美国西南医学中心基础研究访问学者、英国伯明翰大学临床研究访问学者。现任中山大学附属第一医院精准医学研究院副院长、药物临床试验机构主任、临床研究中心副主任。中国医院协会健康医疗大数据应用管理专委会常委、广东省干（体）细胞临床研究专家委员会委员。

论著：

迄今以第一作者或通讯作者（含共同通讯）发表论著40 余篇，分布在Lancet Digital Health、Hepatology、Annals of Oncology、Clinical Cancer Research、American Journal of Gastroenterology等国际权威学术期刊。主持国自然面上及广东省工信厅财政专项等国家及省部级资金项目，获资助超1200万。基于专科系列研究，先后荣获2018年国际消化疾病协会杰出学者奖，多项研究成果被国际消化病诊治指南推荐，2019年获得广东省科技进步一等奖。

(1) Xiang X, Hao Y, Cheng C, Hu H, Chen H, Tan J, Wang Y, Liu X, Peng B, Liao J, Wang J, Xie Y, Liu J, Chen S, Xu L, Xie W, Xue R, Kuang M, Xu Z, Jiang H, Peng S. A TGF-β-dominant chemoresistant phenotype of hepatoblastoma associated with aflatoxin exposure in children. Hepatology. 2024 Mar 1;79(3):650-665. doi: 10.1097/HEP.0000000000000534. Epub 2023 Jul 17. PMID: 37459556.

（2）Xiao H, Weng Z, Sun K, Shen J, Lin J, Chen S, Li B, Shi Y, Kuang M, Song X, Weng W, Peng S. Predicting 5-year recurrence risk in colorectal cancer: development and validation of a histology-based deep learning approach. Br J Cancer. 2024 Apr;130(6):951-960. doi: 10.1038/s41416-024-02573-2. Epub 2024 Jan 20. PMID: 38245662; PMCID: PMC10951272.

（3）Wang Y, Xiang X, Chen H, Zhou L, Chen S, Zhang G, Liu X, Ren X, Liu J, Kuang M, Jiang J, She J, Zhang Z, Xue R, Jiang H, Wang J, Peng S. Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma. Cell Rep Med. 2023 May 16;4(5):101044. doi: 10.1016/j.xcrm.2023.101044. PMID: 37196629; PMCID: PMC10213871.

（4）Chen Z, Zhang G, Ren X, Yao Z, Zhou Q, Ren X, Chen S, Xu L, Sun K, Zeng Q, Kuang M, Kuang DM, Peng S. Cross-talk between Myeloid and B Cells Shapes the Distinct Microenvironments of Primary and Secondary Liver Cancer. Cancer Res. 2023 Nov 1;83(21):3544-3561. doi: 10.1158/0008-5472.CAN-23-0193. PMID: 37352379.

（5）Peng H, Chen B, Wei W, Guo S, Han H, Yang C, Ma J, Wang L, Peng S, Kuang M, Lin S. N6-methyladenosine (m6A) in 18S rRNA promotes fatty acid metabolism and oncogenic transformation. Nat Metab. 2022 Aug;4(8):1041-1054. doi: 10.1038/s42255-022-00622-9. Epub 2022 Aug 23. PMID: 35999469.

（6）Peng S, Chen S, Hu W, Mei J, Zeng X, Su T, Wang W, Chen Z, Xiao H, Zhou Q, Li B, Xie Y, Hu H, He M, Han Y, Tang L, Ma Y, Li X, Zhou X, Dai Z, Liu Z, Tan J, Xu L, Li S, Shen S, Li D, Lai J, Peng B, Peng Z, Kuang M. Combination Neoantigen-Based Dendritic Cell Vaccination and Adoptive T-Cell Transfer Induces Antitumor Responses Against Recurrence of Hepatocellular Carcinoma. Cancer Immunol Res. 2022 Jun 3;10(6):728-744. doi: 10.1158/2326-6066.CIR-21-0931. PMID: 35476700.

（7）Chen S, Xie Y, Cai Y, Hu H, He M, Liu L, Liao C, Wang Y, Wang J, Ren X, Zeng Q, Peng H, Shen S, Li S, Li D, Lai J, Peng B, Ren J, Kuang M, Peng S. Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma. Clin Cancer Res. 2022 May 2;28(9):1896-1910. doi: 10.1158/1078-0432.CCR-21-1157. PMID: 34526363.

（8）Wang F, Wang FH, Sun K, Jiang C, Peng S, Xu LX, Kuang M, Guo GF, Chen SL. PD-1-mAb Plus Regimen in the First and Second Lines of Advanced and Unresectable Biliary Tract Carcinoma: A Real-World, Multicenter Retrospective Analysis. J Inflamm Res. 2022 Oct 31;15:6031-6046. doi: 10.2147/JIR.S364303. PMID: 36339826; PMCID: PMC9635481.

（9）Wang J, Deng C, Liu M, Liu Y, Li L, Huang Z, Shang L, Jiang J, Li Y, Mo R, Zhang H, Liu M, Peng S, Xiao H. A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain. Nat Commun. 2022 Nov 11;13(1):6866. doi: 10.1038/s41467-022-34633-7. PMID: 36369243; PMCID: PMC9651894.

（10）Liu Y, Zhang H, Yuan G, Yao M, Li B, Chen J, Fan Y, Mo R, Lai F, Chen X, Li M, Chen B, Lord JM, Peng S, Cheng K, Xiao H. The impact of circadian rhythms on the immune response to influenza vaccination in middle-aged and older adults (IMPROVE): a randomised controlled trial. Immun Ageing. 2022 Oct 17;19(1):46. doi: 10.1186/s12979-022-00304-w. PMID: 36253778; PMCID: PMC9574181.

（11）Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic chol15angiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863.

（12）Chu H, Liu Z, Liang W, Zhou Q, Zhang Y, Lei K, Tang M, Cao Y, Chen S, Peng S, Kuang M. Radiomics using CT images for preoperative prediction of futile resection in intrahepatic cholangiocarcinoma. Eur Radiol. 2021 Apr;31(4):2368-2376. doi: 10.1007/s00330-020-07250-5. Epub 2020 Oct 8. PMID: 33033863.

（13）Peng S, Liu Y, Lv W, Liu L, Zhou Q, Yang H, Ren J, Liu G, Wang X, Zhang X, Du Q, Nie F, Huang G, Guo Y, Li J, Liang J, Hu H, Xiao H, Liu Z, Lai F, Zheng Q, Wang H, Li Y, Alexander EK, Wang W, Xiao H. Deep learning-based artificial intelligence model to assist thyroid nodule diagnosis and management: a multicentre diagnostic study. Lancet Digit Health. 2021 Apr;3(4):e250-e259. doi: 10.1016/S2589-7500(21)00041-8. Erratum in: Lancet Digit Health. 2021 Jul;3(7):e413. PMID: 33766289.

（14）Chen SL, Xiao H, Xie ZL, Shen JX, Chen ZB, Wang YQ, Li B, Peng ZW, Kuang M, Lai JM, Peng S. The presence of microvascular invasion guides treatment strategy in recurrent HBV-related HCC. Eur Radiol. 2020 Jun;30(6):3473-3485. doi: 10.1007/s00330-019-06640-8. Epub 2020 Feb 11. PMID: 32048035.

（15）Huang M, He M, Guo Y, Li H, Shen S, Xie Y, Li X, Xiao H, Fang L, Li D, Peng B, Liang L, Yu J, Kuang M, Xu L, Peng S. The Influence of Immune Heterogeneity on the Effectiveness of Immune Checkpoint Inhibitors in Multifocal Hepatocellular Carcinomas. Clin Cancer Res. 2020 Sep 15;26(18):4947-4957. doi: 10.1158/1078-0432.CCR-19-3840. Epub 2020 Jun 11. PMID: 32527942.

（16）Xu LX, He MH, Dai ZH, Yu J, Wang JG, Li XC, Jiang BB, Ke ZF, Su TH, Peng ZW, Guo Y, Chen ZB, Chen SL, Peng S, Kuang M. Genomic and transcriptional heterogeneity of multifocal hepatocellular carcinoma. Ann Oncol. 2019 Jun 1;30(6):990-997. doi: 10.1093/annonc/mdz103. PMID: 30916311; PMCID: PMC6594462.

（17）Liao J, Jin H, Li S, Xu L, Peng Z, Wei G, Long J, Guo Y, Kuang M, Zhou Q, Peng S. Apatinib potentiates irradiation effect via suppressing PI3K/AKT signaling pathway in hepatocellular carcinoma. J Exp Clin Cancer Res. 2019 Nov 6;38(1):454. doi: 10.1186/s13046-019-1419-1. PMID: 31694662; PMCID: PMC6836669.