医疗特长:
从事原发和转移性骨肿瘤和软组织肿瘤的精准诊断、外科手术及靶向免疫治疗。擅长(1)骨肉瘤、软骨肉瘤、尤文肉瘤、滑膜肉瘤等肿瘤广泛切除和假体重建,在复杂四肢、骨盆和脊柱肿瘤的精准切除、3D打印假体重建、儿童可延长假体重建方面具有丰富经验;(2)转移性骨肿瘤,尤其是脊柱转移癌的综合外科治疗,包括微创治疗、整块切除重建,创造无瘤生存条件,提高患者生活质量。(3)骨巨细胞瘤的靶向药物治疗和外科手术治疗。
研究方向:
青少年恶性骨肿瘤的精准切除和可延长假体重建;脊柱转移癌的综合外科治疗
主要教育和工作经历:
1997.09-2003.06 山东大学临床医学系 学士学位
2003.09-2008.12 中山大学附属第一医院骨肿瘤科 博士学位
2007.09-2008.09 美国MD Anderson癌症中心 博士后
2009.7-2011.12 中山大学附属第一医院骨肿瘤科 住院医生
2011.12-2013.12 中山大学附属第一医院骨肿瘤科 主治医师
2013.12-2019.12 中山大学附属第一医院骨肿瘤科 副主任医师
2020.01-至今 中山大学附属第一医院骨肿瘤科 主任医师
社会兼职:
中国抗癌协会肉瘤专业委员会 委员
中国抗癌协会肉瘤专业委员会基础研究学组 副组长
中国抗癌协会肉瘤专业委员会化放疗学组 委员
中国抗癌协会肉瘤专业委员会软组织肉瘤学组 委员
中华医学会骨科分会骨肿瘤学组四肢工作委员会 委员
中国医药教育协会骨与软组织肿瘤专业委员会 委员
广东省医学会肿瘤学分会 委员
《中华关节外科杂志(电子版)》 特约审稿人
《实用医学杂志》 特约审稿人
论著:
发表SCI收录文章40余篇,其中第一/共同第一/通讯发表16篇,单篇最高影响因子16.806。
以第一/共同第一/通讯作者发表的SCI文章:
- Lu B, Zou C*(共一), Yang M, He Y, He J, Zhang C, Chen S, Yu J, Liu KY, Cao Q, Zhao W.Pharmacological Inhibition of Core Regulatory Circuitry Liquid-liquid Phase Separation Suppresses Metastasis and Chemoresistance in Osteosarcoma. Adv Sci (Weinh). 2021 Aug 25:e2101895. doi: 10.1002/advs.202101895.
- Wa Q, Zou C*(共一), Lin Z, Huang S, Peng X, Yang C, Ren D, Xu D, Guo Y, Liao Z, Wang B, Hu H, Huang S, He P.Ectopic Expression of miR-532-3p Suppresses Bone Metastasis of Prostate Cancer Cells via Inactivating NF-κB Signaling. Mol Ther Oncolytics. 2020 Apr 7;17:267-277. doi: 10.1016/j.omto.2020.03.024. eCollection 2020 Jun 26
- Li X, Wang L, Wang L, Yu J, Lu G, Zhao W, Miao C, Zou C#(共同通讯), Wu J#.Overcoming therapeutic failure in osteosarcoma via Apatinib-encapsulated hydrophobic poly(ester amide) nanoparticles. Biomater Sci. 2020 Oct 1. doi: 10.1039/d0bm01296c.
- Zhang J*, Liu W*, Zou C*(共一), Zhao Z, Lai Y, Shi Z, Xie X, Huang G, Wang Y, Zhang X, Fan Z, Su Q, Yin J, Shen J.Targeting Super-Enhancer-Associated Oncogenes in Osteosarcoma with THZ2, a Covalent CDK7 Inhibitor. Clin Cancer Res. 2020 Jun 1;26(11):2681-2692.
- Zou C*, Zhao Z*, Lin T, Huang Y, Xie X, Yin J, Huang G, Wang B, Shen J.Long-term outcomes of limb salvage treatment with custom-made extendible endoprosthesis for bone sarcoma around the knee in children. J Orthop Surg Res. 2020 Jan 16;15(1):14. doi: 10.1186/s13018-019-1534-x.
- Lu B, He Y, He J, Wang L, Liu Z, Yang J, Gao Z, Lu G, Zou C, Zhao W.Epigenetic Profiling Identifies LIF as a Super-enhancer-Controlled Regulator of Stem Cell-like Properties in Osteosarcoma. Mol Cancer Res. 2020 Jan;18(1):57-67. doi: 10.1158/1541-7786.MCR-19-0470. Epub 2019 Oct 15.
- Wa Q, Huang S, Pan J, Tang Y, He S, Fu X, Peng X, Chen X, Yang C, Ren D, Huang Y, Liao Z, Huang S, Zou C。 miR-204-5p Represses Bone Metastasis via Inactivating NF-κB Signaling in Prostate Cancer. Mol Ther Nucleic Acids. 2019 Dec 6;18:567-579. Epub 2019 Sep 18.
- Zou C#, Lin T#, Wang B, Zhao Z, Li B, Xie X, Huang G, Yin J, Shen J.Managements of giant cell tumor within the distal radius: A retrospective study of 58 cases from a single center.J Bone Oncol. 2018 Dec 14;14:100211. doi: 10.1016/j.jbo.2018.100211. eCollection 2019 Feb.
- Wang B, Zou C(共一), Hu X, Tu J, Yao H, Yin J, Huang G, Xie X, Shen J. Reconstruction with a novel combined hemipelvic endoprosthesis after resection of periacetabular tumors involving the sacroiliac joint: a report of 25 consecutive cases.BMC Cancer. 2019 Aug 30;19(1):861.
- Shuai Huang, Changye Zou(共一), Yubo Tang, Qingde Wa, Xinsheng Peng, Xiao Chen, Chunxiao Yang, Dong Ren, Yan Huang, Zhuangwen Liao, Sheng Huang, Xuenong Zou, Jincheng Pan.miR-582-3p and miR-582-5p Suppress Prostate Cancer Metastasis to Bone by Repressing TGF-β Signaling Mol Ther Nucleic Acids. 2019 Jun 7; 16: 91–104
- Liu W#, Zhang J#, Zou C#(共同第一作者), Xie X, Wang Y, Wang B, Zhao Z, Tu J, Wang X, Li H, Shen J*, Yin J*. Miceoarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma, Cell Physiol Biochem, 2017;43(3):969-985.
- Wu J, Sun H1, Li J, Guo Y, Zhang K, Lang C, Zou C(共同通讯), Ma H.Increased survival of patients aged 0-29 years with osteosarcoma: A period analysis, 1984-2013.Cancer Med. 2018 Jul 10. 2018 Aug;7(8):3652-3661
- Zou C#, Shen J#, Tang Q, Yang Z, Yin J, Li Z, Xie X, Huang G, Lev D, Wang J*,Cancer-testis antigens expression in osteosarcoma identified by gene microarray correlate with poor prognosis CANCER, 2012 Apr 1;118(7):1845-55
- Zou C#, Smith KD#, Liu J, Lahat G, Myers S, Wang WL, Zhang W, McCutcheon IE, Slopis JM, Lazar AJ, Pollock RE*, Lev D*, Clinical, pathological and molecular variables predictive of malignant peripheral nerve sheath tumor (MPNST) outcome Ann Surg. 2009 Jun;249(6):1014-22.
- Zou CY#, Smith KD#, Zhu QS, Liu J, McCutcheon IE, Slopis JM, Meric-Bernstam F, Peng Z, Bornmann WG, Mills GB, Lazar AJ, Pollock RE, Lev D*. Dual targeting of AKT and mTOR: a potential therapeutic approach for malignant peripheral nerve sheath tumor. Mol Cancer Ther. 2009 May;8(5):1157-68..
- Zou CY, Wang J, Shen JN*, Huang G, Jin S, Yin JQ, Guo QC, Li HM, Luo L, Zhang M, Zhang LJ. Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases Acta Pharmacol Sin. 2008 Mar;29(3):325-32
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专著:
无
其他主要工作成绩(比如获奖情况):
2012年作为青年骨干入选中山大学青年教师重点培育项目及中山大学附属第一医院优秀青年人才支持计划,作为负责人承担国家自然科学面上基金2项、省科技基金项目3项、高校专项基金项目3项。